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Relative contribution of aging and menopause to changes in lean and fat mass in segmental regions

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Palanivel Kandasamy and others introduced KRAS mutations into CRC cells in culture medium containing different concentrations of glutamine and reported that compared with wt KRAS CRC cells, mutant KRAS CRC cells had a significantly lower proliferation rate and a lower glutamine concentration

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3.2 NLRP3 interactions with low-grade inflammation and senescence As previously discussed, aging is associated with an increase in self-derived and dietary signals, oxidative stress from mitochondrial dysfunction, and elevated cytokines, all of which can prime or activate NLRP3