Reduced lipoapoptosis, Hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis
Notably, curcumin activates 5-adenosine monophosphate-activated protein kinase (AMPK) and inhibits mTOR (Zuo et al., 2021), remodels autophagy homeostasis to eliminate UV-induced damaged proteins, and regulates the Bcl-2/caspase-3 balance (Liu et al., 2018) and CD39/CD73-adenosine pathway (Manica et al., 2024), achieving a precise balance between anti-apoptosis and pro-repair
Its ability to activate autophagy, leading to increased angiogenesis, reduced apoptosis, and diminished oxidative stress, is particularly notable Trehalose stimulates the expression of Vascular Endothelial Growth Factor (VEGF) and cadherin 5, alongside an increase in MMP9 expression, thereby augmenting the viability of skin flaps
Additionally, C-X-C chemokine ligand 12 (CXCL-12), also known as stromal cell-derived factor-1 (SDF-1), and C-X-C chemokine receptor type 4 (CXCR4) are chemokines responsible for facilitating the entry of bone marrow-derived cells (BMDC) into irradiated tissue [27]
Full list of ingredients: Water, Centella Asiatica Extract (22.7%), Glycerin, Cetyl Ethylhexanoate, Butylene Glycol, Polyglyceryl-3 Methylglucose Distearate, Niacinamide (20,000ppm), Stearic Acid, Sodium Polyacryloyldimethyl Taurate, Silica, Sodium Hyaluronate, Glyceryl Stearate, Beeswax, Butyrospermum Parkii (Shea) Butter, Macadamia Ternifolia Seed Oil, Hydrogenated Polydecene, Betaine, Glutathione (1,000ppm), Trehalose, Adenosine, Citric Acid, Trideceth-10, Disodium EDTA, Sodium Citrate, Caprylic/Capric Triglyceride, Hydrogenated Lecithin, Cholesterol, Xanthan Gum, Nelumbo Nucifera Extract, Artemisia Annua Extract, Oryza Sativa (Rice) Extract, Saccharomyces Ferment, Solanum Melongena (Eggplant) Fruit Extract, Melaleuca Alternifolia (Tea Tree) Leaf Extract, Hydroiyzed Collagen, Squalane, Beta-Glucan, Ascorbic Acid, Dipropylene Glycol, Hippophae Rhamnoides Fruit Extract, Madecassic Acid, Asiaticoside, Asiatic Acid, Propanediol, Hydroxyacetophenone, 1,2-Hexanediol, Ethylhexylglycerin, Dipotassium Glycyrrhizate
MARCH5-dependent NLRP3 ubiquitination is required for mitochondrial NLRP3-NEK7 complex formation and NLRP3 inflammasome activation
