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Neurological, respiratory, musculoskeletal, cardiac and ocular side-effects of anti-PD-1 therapy

During the conversion of isocitrate to -KG, Idh1 catalyzed the generation of NADPH, and NADPH and reduced nicotinamide adenine dinucleotide (NADH) were reductants for lipid biosynthesis and antioxidants that protect cells from oxidative stress and radiation damage [77]

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Amyotrophic lateral sclerosis (ALS): Preliminary data shows that Sermorelin treatment can slow down muscle strength decline by 22% and prolong respiratory function maintenance time by 18% in ALS patients, which may be related to the neuroprotective effect of GH