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Preclinical studies have demonstrated that dnEFT, which is applied via a clinical-grade spinal cord stimulator or a custom two-electrode system, induces apoptosis in GBM cells and significantly reduces the tumor burden in vivo

The applicant should respond with an appropriate answer to the query

CPZ effect on iron involves disrupting iron homeostasis in the brain leading to increased iron accumulation in brains white matter, particularly in regions undergoing demyelination

Toth A, et al

2-(Phenylazo)pyridineplatinum(II) catecholates showing photocytotoxicity, nuclear uptake, and glutathione-triggered ligand release

If the plasma level is in the high-risk region of the nomogram, the risk of developing hepatotoxicity is 60% or higher, and antidote therapy is warranted