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3.1.2 Roles of ROS in the pathophysiology of other diseases 3.1.2.1 Liver diseases The liver is the second largest organ in the organisms body

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Given the importance of this organelle, maintenance of proper mitochondrial function and structure is essential, and dysfunction is a pathological hallmark of metabolic, muscular, and neurodegenerative conditions, which can be associated with aging in multiple tissues 88,89

Moreover, Notch-1 is known to be strongly expressed in the perivascular area of synovial tissues and ROS can also induce the formation of vascular opacities by upregulating the expression of vascular endothelial growth factor (VEGF) and Notch-1 (53)

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Edaravone protects against glutamate-induced PERK/EIF2/ATF4 integrated stress response and activation of caspase-12