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Clinical Translation : As such, while animal and in vitro models have shown that targeting lipid peroxidation is a potential therapeutic approach, a proper clinical application of this knowledge will require robust test in properly designed clinical trials

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Some examples include PNU-282987, which was demonstrated to enhance learning and memory in preclinical studies, and TC-5619, which exhibited positive effects on cognitive function in animal models

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In the second step, GSSG is reduced via the thiol-disulfide interchange reaction (Rao and Reddy 2008