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Neelakantan H, Wang H-Y, Vance V, Hommel JD, Mchardy SF, Watowich SJ (2017) Structure-activity relationship for small molecule inhibitors of nicotinamide N -Methyltransferase

But heres the thingunlike many of the other amino acids, it is unique, because it is the primary fuel used by the cells in your gut lining 3

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This increases cost without clear benefit and eliminates the ability to increase dose if initial response is insufficient