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Forty postmortem examinations in COVID-19 patients

Beyond iron overload, whether iron depletion modulates ferroptosis thresholds by impairing mitochondrial respiratory chain complexesaffecting membrane potential and ROS generationrequires validation using conditional iron transporter knockout, iron chelators, and real-time mitochondrial monitoring (123, 124)

Multiple studies have demonstrated that MSC-Exos attenuate ferroptosis in chondrocytes by targeting key molecular axes

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For instance, the specific SIRT1 activator SRT2104, in combination with the LDHA inhibitor oxamate, successfully blocks the malignant progression of GC mediated by H3K18la, showing significant antitumor effects with minor adverse reactions (159)

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