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490 On the basis of the above findings, we can also predict patients specific responses to p53-targeted therapies and design more effective combination therapies via systems biology methods

This specific bacterium metabolizes the primary BA chenodeoxycholic acid (CDCA) into iso-LCA, which subsequently accumulates in the liver ( 2.1.3 Myeloid-derived suppressor cells: bile acid-mediated regulation Myeloid-derived suppressor cells (MDSCs), a heterogeneous population of immature myeloid cells with strong immunosuppressive activity, play a pivotal role in tumor immune evasion and metastasis ( Among these, conjugated and secondary BAs, particularly taurocholic acid (TCA) and deoxycholic acid (DCA), exert notable effects on MDSCs

Diet and asthma: looking back, moving forward

Regulation of Methionine Metabolism The enzymes involved in methionine metabolism are tightly regulated to maintain cellular homeostasis