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If you are achieving your research objectives at 1.0mg with manageable side effects, there is no clinical requirement to increase further

Diclofenac was also reported to improve dyslipidaemia and hyperglycaemia associated with diabetes mellitus (107)

Proc Natl Acad Sci U S A 90:97309734 Wadleigh DJ, Reddy ST, Kopp E, Ghosh S, Herschman HR (2000) Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages

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The performance benefits that result from creatine supplementation include higher cellular energy for short, high-intensity exercise, improved energy transfer in muscle cells, greater buffering capacity resulting in less fatigue and shorter recovery time (Nelson et al., 2001