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[4] Cell Line:PC12 cells Concentration:4 mM Incubation Time:2 h pretreatment + 12 h cadmium exposure Result:Significantly reduced the number of TUNEL-positive PC12 cells

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Gene 592, 110118

At the molecular level, it has been reported that glucocorticoid receptors (GR) located in the HPA axis regulating limbic regions are downregulated in response to stress, possibly as part of a negative feedback mechanism against chronic secretion of cortisol [32]