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We also agree with the commenter that the proposal for calculating the payment limit for a biosimilar for which negative or zero ASP data are reported for all NDCs is dissimilar from the methodology provided in statute for circumstances when positive manufacturer's ASP data is available

AC5 and AC6 as potential drug targets for cardiovascular disease Although AR agonists and antagonists have therapeutic effectiveness for heart failure treatment, there are still patients who do not respond effectively

Furthermore, the potential of traditional-medicine-derived active compounds, repurposed drugs, and de-novo synthetic small molecules to induce dual death should be thoroughly explored

The activity of CAT was decreased in the roots but remained unchanged in the leaves of As-treated plants with GSH, compared with As treatment ( Figure 3B )

Potential interactions with drugs metabolized by methyltransferases should be considered