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Furthermore, the following studies have demonstrated an overexpression of matrix metalloproteinases (MMP-1, 2, 3, 7, 9 and 13) in human colorectal cancer (46) and gastric cancer (47)

2.2 Major physiological changes to account for the disease pathology of -synuclein Misfolding of -synuclein has been linked to a plethora of cognitive ailments arising from the death of dopaminergic neurons and collectively referred to as synucleinopathies