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The later nanoprobe may further swell in response to the acidic microenvironment after targeting the tumor site, heightening the LFUS-induced cavitation effect of BEAGA/ApoE-PDHD (Fig

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Additionally, mutations in mice that decrease levels of circulating insulin and IGF-1, such as Prop-1 df/df and Ghrhr lit/lit (the Ames and Little dwarf mice), also increase lifespan [13, 14]