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It also disrupts ER Ca 2+ pool homeostasis, triggering ERS, interfering with protein degradation, and leading to protein accumulation

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[8] Function [edit] SOD1 binds copper and zinc ions and is one of three superoxide dismutases responsible for destroying free superoxide radicals in the body

using the m/z isolation window 305.3 0.5

The substantial processing and thus depletion of cell lysate (input) precursor IL-1 by recombinant Caspase-1 further indicates that the majority of IL-1 in a cell at any one time is not ubiquitylated (Fig