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Two distinct mechanisms, inflammation and delayed hypersensitivity, are known to be involved in the mediation of adjuvant arthritis

FoxO activity is finely regulated by cofactors such as HDAC6, PGC-1, and GADD45, and by miRNAs including miR-182, miR-486, and miR-23

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Mechanism involves NO system modulation (homeostatic regulationupregulating when deficient, moderating when excessive), VEGF/VEGFR2 upregulation for angiogenesis, FAK-paxillin pathway activation for cell migration (40% increase per Chang et al.), and EGR-1 transcription factor upregulation for growth factor sensitivity