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SLU-PP-332 and 5-amino-1mq have distinct mechanisms of action

MELATONIN SYNTHESIS AND METABOLISM Melatonin Synthesis Melatonin (N-acetyl-5-methoxytryptamine) is synthesized within the pinealocytes from tryptophan, mostly occurring during the dark phase of the day, when there is a major increase in the activity of serotonin-N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT), responsible for the transformation of 5-hydroxytryptamine (5HT, serotonin) to N-acetylserotonin (NAS) (Figure 1)

Under physiological conditions, the antioxidant system in the body, covering antioxidant enzymes [superoxide dismutase, catalase (CAT), and glutathione (GSH) peroxidase (GPX)] and antioxidants (vitamins C and E, flavonoids, carotenoids, GSH, and micronutrients), is involved in maintaining the dynamic balance between ROS production and metabolism

An ton cho da: Sn phm dc m phm tin phong i km vi cc chng nhn lm sng, nghin cu phn tch mang li pH chun (3.7-5.7) rt an ton, lnh tnh v hn ch kch ng trn da, k c da nhy cm

PMID: 17671020

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