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It is postulated that neurotransmitters or neurochemicals released by nerve endings, specifically substance P, can be toxic to melanocytes, causing their destruction in specific areas.92,93 The segmental distribution of vitiligo patches corresponds to the innervation of certain nerves, supporting this hypothesis.92,93 A study analyzing the presence of VZV in segmental vitiligo skin suggests a possible relationship between the 2

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89 We found that in long-term Enza-treated VCaP16 cells, ARv7 ChIP-seq revealed a subtle but notable increase in ARBS1 binding upon DHT stimulation (supplementary Fig