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(Bear with me, Im getting to the point soon, I promise.) When the body takes a large oxidative hit it causes the depletion of active glutathione

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doi:10.1038/sj.cdd.4401776 61

[DOI] [PubMed] [Google Scholar] 226.Libert S., Pointer K., Bell E., Das A., Cohen D., Asara J., Kapur K., Bergmann S., Preisig M., Otowa T., et al

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When eNOS knockout mice are subjected to experimental varicocele induction, impaired NO production appears to aggravate vascular dysfunction and testicular injury, suggesting that eNOS-derived NO is essential for preserving local blood flow, endothelial integrity, and tissue homeostasis under varicocele-related stress conditions (122, 123)