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10.1016/S2213-2600(17)30310-7 10 BonellaF.SpagnoloP.RyersonC

PMID: 30710793 Inflammation2023 Feb;46(1):404-417

During the pathogenic conditions of systemic and chronic SLE, mitophagy and mitochondrial metabolism pathways form extremely complex networks that mutually affect immune signaling activation (184)

Spach ( Polygonum hydropiper L.)

The homogenate extract from both Zebrafish larvae and the CAM layer of chick embryo was centrifuged at 12,000 g for 15 min at 4 C to remove cellular debris

Thus, damage to mitochondrial DNA and loss of can further increase ROS production, thereby creating a cycle of dysfunction that includes increased ROS production by the respiratory chain, activation of signal transduction pathways, and potentially, leading to apoptosis or necrosis, as well as the release of cytochrome c, which triggers apoptosis