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This is consistent with results from other in vitro studies involving human cells ( To the best of our knowledge, placental villi explants have not been utilized to investigate the uptake or toxicity of MPs, a fact supported by a review of human in vitro and ex vivo placental models ( in vitro

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doi: 10.3389/fphar.2026.1776868 Received 28 December 2025 Revised 28 February 2026 Accepted 02 March 2026 Published 07 April 2026 Volume 17 - 2026 Edited by Yongsheng Chen, Jinan University, China Reviewed by Hamidreza Pazoki-Toroudi, Iran University of Medical Sciences, Iran Liping You, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, China Updates Copyright 2026 Wang, Jiang, Huang, Zhang, Qi, Xu, Sun and Liu

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