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Such results may appear to contradict the systems antioxidant function, but it has been shown that endogenous thioredoxin increases the redox cycling of anthracyclines and enhances their apoptotic potential

they therefore are integral to the molecular sub-classification of tumors and cellular health

The use of epi-drugs alone, or in combination with chemotherapy or immunotherapy, has shown compelling outcomes, including augmentation of anti-tumoral effects, overcoming drug resistance, and activation of host immune response