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Indeed, accumulating evidence based on preclinical studies has identified ERK5 activation as a mediator of resistance to vemurafenib (BRAFi) and trametinib (MEKi) [54], and therefore, the combined targeting of ERK5 and ERK1/2 pathways results in better outcomes [55]

The findings suggest these polyphenols may regulate genes involved in lipid and glucose metabolism and influence glucose absorption and utilization, contributing to the normalization of fasting blood glucose levels (379)

Koizumi S, Okada Y, Miura S, et al

Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-1: potential role in idiopathic pulmonary fibrosis

Takahashi S, Rousseau RF, Yotnda P, Mei Z, Dotti G, Rill D, Hurwitz R, Marini F, Andreeff M , Brenner MK

Similarly, CBD may interact with systems that have high levels of redundancy, or similar downstream processes (Mantovani 2018)