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G.CoenM.OrtegaF.et al

It does so by blocking the enzyme that triggers melanin production in the skin

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The APE1 inefficiently cleaves but recruits various transcription factors to activate downstream genes, such as vascular endothelial growth factor (VEGF) and endonuclease IIIlike protein 1 (NTHL1) [95]

Hangauer and coworkers demonstrated that persister cells broadly downregulate antioxidant programs and become highly dependent on glutathione peroxidase 4 (GPX4) to prevent lethal lipid peroxidation 12 , a vulnerability later corroborated in a preprint study 49

Panel A shows the steady state value of GSH as a function of the parameter S, which increases with estradiol concentration and is defined in formula (2)