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2.13.3 Native mass spectrometry (nMS) Native mass spectrometry (nMS, which is a form of electrospray ionization mass spectrometry (ESI-MS)), being a relatively recent addition to the analytical toolbox of mass spectrometry, can be used to measure the size, stoichiometry, and interactions of macromolecules (such as proteins) in their native, folded state, thereby directly exploring the different conformational components in terms of geometry and structural compactness (Konijnenberg et al., 2015

As I mentioned earlier, according to a 2016 study published in Currents in Neuropharmacology, it may also support the gut-brain barrier, which is critical for your gut and brain health ( 7 )

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Oral B12 supplementation may be appropriate in specific circumstances: Dietary deficiency in individuals with normal absorption capacity (typically 50-150 micrograms daily) Patient preference (after discussion of relative efficacy) Maintenance therapy in selected cases Higher oral doses (10002000 micrograms daily) may be used in some cases, as only a small percentage is absorbed through passive diffusion when intrinsic factor-mediated absorption is impaired