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Certain groups should exercise particular caution or avoid BPC-157 entirely: individuals with active cancer or significant cancer history, pregnant or breastfeeding women (no safety data exists), those taking blood thinners (potential interaction effects), and anyone with autoimmune conditions affecting connective tissue

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Amongst the different cellular compartments, the mitochondria and the endoplasmic reticulum are affected the most by ischemia, mainly because of their capability to sense oxidative stress, maintain ion homeostasis, and trigger apoptosis