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Whatever the underlying causes, AnxDs are transdiagnostically associated with chronically or recurrently elevated anxiety and arousal [10, 11] with attendant neurobiological adaptations that may themselves have pathogenic consequences

10.1016/j.tox.2020.152599 168 YaoF.DengY.ZhaoY.MeiY.ZhangY.LiuX.et al (2021)

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Selecting the preserved formulation allows for multiple punctures over a 28-day beyond-use window post-opening, whereas the preservative-free formulation provides a pure, additive-free profile for high-dose or high-sensitivity applications