foxo4-dri senolytic human trial 2024 peptide What if aging cells could be removed? As we Therapeutic targeting of senescent cells

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We demonstrated using NMR that FOXO4DRI peptide competes with FOXO4 for p53 binding and therefore can efficiently interfere with the FOXO4 p53 interaction Mechanistically, FOXO4DRI promotes nuclear exclusion of active p53