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10.1007/s11033-022-07788-1 28 JungY

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Immunotherapies in development for early-stage T1D may be applicable in islet cell transplant settings, including approaches that retrain the immune system to ignore beta cellsan area that Breakthrough T1D is invested in

Biomaterials 52:507516

People with inflammatory arthritis are about twice as likely to get shingles as otherwise-healthy adults, which is likely due to immune dysfunction from the disease itself and/or the immune-suppressing drugs people take to treat their arthritis

This is relevant since paramyxoviral IFN antagonists bind one STAT and induce degradation of another, for example STAT1 is needed by human parainfluenza virus 2 to target STAT2, while STAT2 is required for both simian virus 5 (SV5) and mumps V proteins to target STAT1 (Ulane et al , 2005)