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PeerJ 6, e6153

The authors reported modestly higher objective sleep efficiency and shorter sleep latency in the DSIP arm versus placebo, but subjective sleep-quality measures did not improve and the authors themselves concluded that short-term treatment of chronic insomnia with DSIP is not likely to be of major therapeutic benefit. That is the strongest controlled human sleep study in the literature, and its conclusion is negative to modest

GI-sensitive individuals benefit from extended 16-20 week titrations and may find optimal results at maintenance doses of 1.8-2.0mg weekly rather than pushing to 2.4mg