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[DOI] [PMC free article] [PubMed] [Google Scholar] 176.Schmidt EE

376 Active mTORC1 promotes the conversion of Tregs to effector-like T cells and further impairs Treg stability and function

Red/blue dots denote positive/negative associations (95% CI)

Furthermore, there was a significant 8-fold increase in the growth of BCG inside granulomas from T2DM subjects compared to the healthy subjects ( Figure 2B )

doi: 10.1016/j.tcb.2014.03.003

The NRF2-dependent effect was identified through the antioxidative response element in target gene loci, while NRF2-independent effects act through DNA 5hmC modifications via the regulation of the metabolite L2HG