glutathione s transferase theta 1 S-transferase π: a potential role in antitumor therapy | DDDT GSTT1 Gene Glutathione S-transferase theta-1

Consistent with these findings, p53 depletion increased proliferation and CFU-F of MSCs by increasing expression of TWIST2, improved osteogenesis at the expense of adipogenesis by suppressing PPARG, and diminishing mitochondrial ROS production, suggesting p53 is a negative regulator of self-renewal and osteogenesis of MSCs [52]

Kobayashi T et al

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Moreover, given the trend towards precision medicine, which accounts for individual differences, factors such as a patients disease stage, comorbidities, and genetic background must also be considered to fully assess the clinical translational potential of these active compounds in diabetes management