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Second, buffer proximity, as SODs, peroxiredoxins, GPx and local GSH pools are co-localized with ROS sources to sculpt H 2 O 2 lifetime and limit its reach and third, pulse design, since short, low-amplitude bursts favor selective thiol switches, whereas sustained or repeated pulses saturate these buffers and allow oxidants to spread to vulnerable macromolecules (Winterbourn 2020)

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In the treatment of AD, microneedles loaded with epigallocatechin gallate, a potent antioxidant, and L-ascorbic acid as a stabilizing reductant, prepared from poly--glutamic acid, exhibit multiple beneficial functions

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Concordantly, both the addition of sodium citrate or SB204990 (an ATP-citrate lyase inhibitor) to the 3D cultures of FASN lox/lox -PyMT phenocopied FASN / -PyMT MEFs: (1) no spheroids were recovered (Fig