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Interventions were grouped into therapeutic classes - including oxytocinergic agents, E/I balance therapeutic targets, metabolic drugs, cannabinoids, purine-based interventions and emerging targets - alongside microbiota-directed strategies such as probiotics, prebiotics, and fecal microbiota transplantation

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Chemiluminescent proteins were revealed in a dark room using Kodak X-ray Plates, and bands intensity quantification was performed by densitometry using Image Studio Lite V