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Ras, Raf, MEK and ERK proteins are key components of this pathway, and abnormal function of any one of them may lead to serious consequences

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Notable advancements, such as uricase-loaded nanocarriers with reduced immunogenicity and pH-responsive hydrogels for sustained urate control, exemplify the shift toward intelligent, patient-centric designs

Morphologically, ferroptosis occurs mainly in cells as reduced mitochondrial volume, increased bilayer membrane density and reduction or disappearance of mitochondrial cristae 1,3 , but the cell membrane remains intact, the nucleus is normal in size, and there is no concentration of chromatin