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The transcription factors ATF4 and Nrf2 couple ER stress to a general cellular response that increases the production of glutathione by increasing aminoacid metabolism (Cullinan et al , 2003

After controlling for sex, age, and BMI z-score, PNPLA3 GG carriers were nearly 20 times more likely to have HS than CC (Odds Ratio [OR] 19.93, p=0.003) and CG carriers nearly 6 times more likely than CC carriers (OR 5.61, p=0.069)

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The glomerular endothelial cells, which have multiple window pores, serve as the first line of defense of the glomerular filtration barrier

Elevated mucin MUC5AC concentration in sputum (when measured with MUC5B) directly associates with disease severity, exacerbation frequency, and lung function decline

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