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Nature 382 , 366370 (1996)

145 Under hypoxia, elevated HIF-2 upregulates SDF-1/CXCR4 in pericyte cells, promoting pericytes to migrate from capillaries to arterioles, where they increase the expression of Calponin and SM22, transforming into smooth muscle cell (SMC)-like cells and contributing to vascular remodeling

These frameworks allow simultaneous testing of multiple therapies or targets within a shared infrastructure, reducing redundancy and accelerating discovery

doi: 10.1016/j.bbamcr.2020.118861 28 LayerG.JahnM.MoserJ.JahnD

By neutralizing localized free radicals within the myelin sheath and the nerve axon itself, ALA helps repair the damaged small unmyelinated fibers responsible for vascular signaling