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Regional ischemia was induced by ligation of the left anterior descending coronary artery with a 4 0 cotton suture for 35 min, followed by 90 min of reperfusion after release of the ligature 60

In granulosa cells of women with endometriosis, elevated lipid peroxidation markers such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) have been observed, accompanied by decreased glutathione (GSH) and glutathione peroxidase 4 (GPx4), key inhibitors of ferroptosis ( Ferroptosis exerts a double-edged effect in endometriosis: while it damages ovarian granulosa cells, oocytes, and embryosdisrupting oocyte maturation, decreasing oocyte retrieval rates, and impairing embryonic developmentit also promotes ectopic lesion growth through downstream signaling pathways that enhance angiogenesis and inflammation ( Therapeutically, ferroptosis inducers can promote lipid ROS accumulation and endometriotic cell death but may exacerbate granulosa cell damage, while ferroptosis inhibitors protect granulosa cells against oxidative damage

Zoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPase inhibition

Guia Prtico da Farmcia Magistral, 6 th ed., 2023.

Adornato, I