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doi: 10.1155/2012/135206

Regulators of coagulation: Thrombomodulin activates the protein C and protein S, also inactivates factor Va and V111a leads to inhibition of intrinsic mechanism of clotting

Potential strategies to reduce the suppressive effects of prostacyclin signaling on T cell function include PTGIS inhibition, PTGIR-blocking antibodies or silencing PTGIR expression in CAR-T cell products