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However, it is imperative to note that findings from animal models cannot be directly extrapolated to clinical trials in humans

For example, individuals with NAFLD exhibit increased intestinal permeability and prevalence of small intestine bacterial overgrowth, and these factors are associated with the severity of hepatic steatosis 19

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Gut Microbes 7 (2), 146153

It might be an enzyme you have never heard of, one that is actively working against your fat loss efforts at the cellular level

A 2021 peer-reviewed review of NNMT in obesity and type 2 diabetes states explicitly that 'clinical trials targeting NNMT have not been reported' meaning every quantitative efficacy figure available for this compound comes from mice, and there is currently zero published human efficacy data