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How epithalon may improve sleep Unlike melatonin supplements, which provide the hormone directly, Epithalon appears to work further upstream

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Systemic pro-inflammatory mediators eventually activate microglia, which leads to neuronal death, inflammation, and BBB rupture, of the nervous system

Central administration of human opiorphin alleviates dextran sodium sulfate-induced colitis in mice through activation of the endogenous opioid system

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Nat Rev Drug Discov 2011