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Luana Stanescu: Nothing to Disclose, Bin Zhang: Nothing to Disclose, Alexander Miethke: Mirum Pharmaceutical Inc: Grant/Research Support, Mirum Pharmaceutical Inc: Consultant, Ipsen: Speaking and Teaching, Jonathan Dillman: GE HealthCare: Grant/Research Support, Philips Healthcare: Grant/Research Support, Motilent: Grant/Research Support, Perspectum: Grant/Research Support, Andrew Trout: Siemens Healthineers: Funding to institution, GE Healthcare: Funding to institution, GE Healthcare: Expert review of images, Perspectum Inc: Funding to institution 2343 SPATIAL HETEROGENEITY OF LIVER STIFFNESS BY MR ELASTOGRAPHY IN PATIENTS WITH PRIMARY SCLEROSIS CHOLANGITIS DOES NOT ASSOCIATE WITH CLINICAL OUTCOMES Erick Cruz Grave 1 Connie Chan 1 Michael Corwin 1 Richard Dean 1 Sandeep Dhaliwal 1 Maryam Yazdanfar 1 Christopher Bowlus 1 , 1 University of California, Davis Background: Primary sclerosing cholangitis (PSC) is a cholestatic liver disease that progresses to cirrhosis and liver failure

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The autoxidation with Fenton chemistry was thought as a spontaneous, non-catalytic process which contributed to the lipid peroxidation ( Ferroptosis induced by RSLs was suppressed by iron chelators such as DFOM and compound311 dependent on their abilities of depleting iron, highlighting the significance of iron in ferroptosis
Year-round use is not recommended due to receptor desensitization and potential for diminishing returns
Getting consistent and adequate sleep also supports hormone balance and can help balance blood sugar and cortisol levels