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To transform preliminary findings into robust clinical guidance, future research must prioritize methodological rigor, targeted populations, and mechanistic clarity

The Zn 2+ -deficient/Cu 2+ -SOD1 WT and fALS WTL SOD1 mutants were shown to efficiently oxidize ascorbate, with a subsequent reoxidation of SOD1-Cu + by oxygen to produce O 2 , which combines with NO afterward to produce peroxynitrite 35

For instance, studies have demonstrated that sorafenib treatment leads to a significant enhancement in glucose uptake and lactate production, which is attributed to the overexpression of key glycolytic enzymes (85)

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