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doi: 10.3389/fmicb.2025.1710051 Received 23 September 2025 Accepted 23 October 2025 Published 06 November 2025 Volume 16 - 2025 Edited by Jianan Zhao, Temple University, United States Reviewed by Jian-Zheng Yang, Southern Medical University, China

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2.2 Pregnancy, delivery, and postpartum factors Exposure to adverse risk factor during pregnancy can significantly impact the normal development of the fetus, leading to impaired neurodevelopment in children

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Mechanistically, SDC4 is required for CAR peptide internalisation, CAR-mediated cytoskeletal reorganisation, ARF6 activity modulation, keratinocyte migration and wound repair

The mean ( k ) and standard deviation ( k ) of the aggregated Z scores, generated by sampling 10,000 sets of k enzymes from the network, were used to adjust the Z metabolite scores for the background distribution (equation 6)