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Argiolas A, Melis MR, Gessa GL

Excretion Pathways Radiolabeled studies in humans established PT-141s elimination pathways: 64.8% of administered dose recovered in urine 22.8% of dose recovered in feces Complete elimination occurring within several days No evidence of accumulation with repeated administration The predominantly renal excretion pattern and absence of accumulation support the approved dosing regimen of no more than one dose per 24 hours and maximum eight doses per month

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This behavior was interpreted as an anxiety response to leaving the familiar, safe environment

992, Journal articles | 2020 Venning VL

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