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In the CALERIE trial, a 2-year randomized controlled multicenter phase 2 clinical trial with 220 adults (age 2050 years), a 1225% reduction in calorie intake did not reduce biological age but slowed the pace of aging using the DunedinPACE DNAm algorithm 98

Thus, folic acid improves eNOS coupling and function, supporting NO production and protecting brain endothelial function

Cysteine and cysteine-dependent metabolites (glutamylcysteine, GSH and hypotaurine) were labelled when cells were grown in medium with 13 C-cystine and became unlabelled when cancer cells were grown in cystine-free medium with unlabelled GSH (Fig

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demonstrated superior antifungal activity of CuO-ZnO hybrids against Aflatoxin B1, attributed to synergistic ROS and metal ion effects (Ngwenya et al., 2025)

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