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Chen E, Chen Z, Chen L, Hu X

Excitotoxicity occurs through over-stimulation of glutamate receptors, specifically NMDAR, while in the non-receptor-mediated pathway, high glutamate concentrations reduce cystine uptake by inhibiting the System Xc-, leading to intracellular glutathione depletion and resulting in ROS accumulation, which contributes to increased lipid peroxidation, mitochondrial damage, and ultimately ferroptosis

Oral squamous cell carcinoma cells protect themselves against ferroptosis by upregulation of RUNT-related transcription factor 2 (RUNX2), a protein connected to survival and metastasis of various cancer types [153]

10.3892/mmr.2013.1668 10 ChanB

Direct detection and quantitative determination of bovine lactoferricin and lactoferrin fragments in human gastric contents by affinity mass spectrometry