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FIGURE 3 4.1 MTH1 regulates the mitotic process of tumor cells Researchers developed a chimeric ATP-releasing guanine oxidation probe (ARGO) that merges 8-oxodGTP and ATP to assess MTH1 enzyme activity in various cancers, including colorectal cancer (CRC), non-small cell lung cancer (NSCLC), and pancreatic ductal adenocarcinoma (PDAC), as well as in corresponding normal tissues

Troglitazone inhibits synthesis of transforming growth factor-beta1 and reduces matrix production in human peritoneal mesothelial cells