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It was first isolated in 1970s from cerebral venous blood of rabbit brains during slow-wave sleep

The suprachiasmatic nucleus, the brain master clock, coordinates the timing of neurotransmitter release, hormone secretion, body temperature, and cellular metabolism

PubMed , Respiratory Research , vol

Dahrouj, M., Desjardins, D

One possible explanation for this observation, which has been under intense investigation for the past two decades, is that blood-borne circulating factors play a key role in regulating tissue regenerative responses and that variations in the level and/or activity of these factors with age are a key determinant of the observed differences in repair activity