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17,20 This mechanism has been implicated in neuropsychiatric disorders such as Alzheimers disease, Parkinsons disease, epilepsy, and anxiety-like behaviors, 16,21,22 suggesting a broader role for astrocytic GABA dysregulation in brain dysfunction

10.1016/j.placenta.2018.10.007 15 ClabaultH.FlipoD.GuibourdencheJ.FournierT.SandersonJ

10.1016/j.jbiosc.2018.04.003 110 ZhouQ.XueB.GuR.LiP.GuQ

Nagy SM, Golumbic C, Stein WH, Fruton JS, Bergmann M

These nanoparticle approaches may eventually address the kidney problem

While its activity is often associated with disease progression through the promotion of ferroptosis and oxidative damage, it also holds potential as a therapeutic target, with selective inhibition of CHAC1 offering possible benefits in conditions where its overexpression drives pathology